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553867

Sigma-Aldrich

2,4-Dichloro-5-fluoro-3-nitrobenzoic acid

97%

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About This Item

Linear Formula:
C6HCl2FNO2COOH
CAS Number:
Molecular Weight:
254.00
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:

assay

97%

form

solid

mp

193-197 °C (lit.)

functional group

carboxylic acid
chloro
fluoro
nitro

SMILES string

OC(=O)c1cc(F)c(Cl)c(c1Cl)[N+]([O-])=O

InChI

1S/C7H2Cl2FNO4/c8-4-2(7(12)13)1-3(10)5(9)6(4)11(14)15/h1H,(H,12,13)

InChI key

PCSAPCNEJUEIGU-UHFFFAOYSA-N

General description

2,4-Dichloro-5-fluoro-3-nitrobenzoic acid can be prepared from 2,4-dichloro-5-fluorobenzoic acid.

Application

2,4-Dichloro-5-fluoro-3-nitrobenzoic acid may be used to synthesize:
  • ethyl 3-(N,N-dimethylamino)-2-(2,4-dichloro-5-fluoro-3-nitrobenzoyl)acrylate
  • 7-chloro-1-cyclopropyl-6-fluoro-8-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
  • ethyl-3-(N,N-dimethylamino)-2-(2,4-dichloro-5-fluoro-3-nitrobenzoyl) acrylate
  • substituted 4(1H)-oxoquinoline-3-carboxylic acid

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Yusuf M Al-Hiari et al.
Molecules (Basel, Switzerland), 13(11), 2880-2893 (2008-11-21)
[1,4]Diazepino[2,3-h]quinolone carboxylic acid 3 and its benzo-homolog tetrahydroquino[7,8-b]benzodiazepine-3-carboxylic acid 5 were prepared via PPAcatalyzed thermal lactamization of the respective 8-amino-7-substituted-1,4-dihydroquinoline-3-carboxylic acid derivatives 8, 10. The latter compounds were obtained by reduction of their 8-nitro-7-substituted-1,4-dihydroquinoline-3-carboxylic acid precursors 7, 9 which, in
Mohammed H Al-Huniti et al.
Molecules (Basel, Switzerland), 12(8), 1558-1568 (2007-10-26)
Substituted [1,4]thiazepino[2,3-h]quinolinecarboxylic acid 3 is prepared by PPA-catalyzed thermal lactamization of the respective 8-amino-7-[(2-carboxyethyl)thio]-1,4-dihydroquinoline-3-carboxylic acid 9. The latter synthon is obtained by reduction of the 8-nitro-1,4-dihydroquinoline precursor 8 which, in turn, is made accessible via interaction of 3-mercaptopropionic acid with
Synthesis and antibacterial activity of 9-cyclopropyl-4-fluoro-6-oxo-6, 9-dihydro-[1, 2, 5] thiadiazolo [3, 4-h] quinoline-7-carboxylic acid and its ethyl ester.
Al-Qawasmeh RA, et al.
ARKIVOC (Gainesville, FL, United States), 12, 322-326 (2009)
Synthesis and antibacterial properties of new 8-nitrofluoroquinolone derivatives.
Al-Hiari YM, et al.
Molecules (Basel), 12(6), 1240-1258 (2007)
M Engler et al.
Antimicrobial agents and chemotherapy, 42(5), 1151-1159 (1998-05-21)
Photodegradation of sparfloxacin was observed by means of high-pressure liquid chromatography with UV detection and liquid chromatography coupled with UV detection and tandem mass spectrometry (LC-MS/MS). Three products were detected. Comparison with an independently synthesized derivative of sparfloxacin revealed the

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