530301

2-(Chloromethyl)-3,4-dimethoxypyridine hydrochloride

97%

• Synonym(s): 2-(Chloromethyl)-3,4-dimethoxypyridinium hydrochloride
• Empirical Formula (Hill Notation): C₈H₁₁Cl₂NO₂
• CAS Number: 72830-09-2
• Molecular Weight: 224.08
• Beilstein/REAXYS Number: 5360726
• EC Number: 416-440-5
• MDL number: MFCD02181083
• UNSPSC Code: 12352100
• PubChem Substance ID: 24877740
• NACRES: NA.22

Properties

• Quality Level: 100
• assay: 97%
• mp: 155 °C (dec.) (lit.)
• functional group: chloro
• SMILES string: Cl[H].COc1ccnc(CCl)c1OC
• InChI: 1S/C8H10ClNO2.ClH/c1-11-7-3-4-10-6(5-9)8(7)12-2;/h3-4H,5H2,1-2H3;1H
• Inchi Key: YYRIKJFWBIEEDH-UHFFFAOYSA-N

Description

General description

2-(Chloromethyl)-3,4-dimethoxypyridine hydrochloride (CDP) can be synthesized using maltol as a starting material. CDP and DMS (dimethyl sulfate) are used in the preparation of pantoprazole sodium (PPS), an antiulcerative drug. The quantification of CDP and DMS in PPS can be done simultaneously by gas chromatography–mass spectrometry (GC-MS) method.

Application

2-(Chloromethyl)-3,4-dimethoxypyridine hydrochloride may be used as a precursor for the preparation [(2-pyridyl)-2-ethyl]-[3,4-dimethoxy-(2-pyridylmethyl)]-N-methylamine.

Safety Information

• pictograms: GHS08,GHS05,GHS07,GHS09
• signalword: Danger
• hcodes: H302 + H312,H315,H317,H318,H373,H411
• pcodes: P273 - P280 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves