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522287

Sigma-Aldrich

Tributylmethylammonium hydroxide solution

20 wt. % in H2O

Synonym(s):

Methyltributylammonium hydroxide

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About This Item

Linear Formula:
[CH3(CH2)3]3N(OH)CH3
CAS Number:
32680-30-1
Molecular Weight:
217.39
MDL number:
MFCD00043104
UNSPSC Code:
12352106
PubChem Substance ID:
24874261

concentration

20 wt. % in H2O

refractive index

n20/D 1.374

bp

102 °C

density

0.993 g/mL at 25 °C

SMILES string

[OH-].CCCC[N+](C)(CCCC)CCCC

InChI

1S/C13H30N.H2O/c1-5-8-11-14(4,12-9-6-2)13-10-7-3;/h5-13H2,1-4H3;1H2/q+1;/p-1

InChI key

QVOFCQBZXGLNAA-UHFFFAOYSA-M

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pictograms

FlameCorrosion
GHS02,GHS05

signalword

Danger

hcodes

H226,H314

Hazard Classifications

Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1B

Storage Class

3 - Flammable liquids

wgk_germany

WGK 3

flash_point_f

132.8 °F - closed cup

flash_point_c

56 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
03530PE
11410KU

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J W Smit et al.
The Journal of pharmacology and experimental therapeutics, 286(1), 321-327 (1998-07-10)
We recently showed that absence of mdr1-type P-glycoprotein (P-gp) in mice resulted in profoundly reduced hepatic and intestinal clearance of type 1 and type 2 cationic drugs compared with that in wild-type mice. These data strongly support the concept that
H Steen et al.
Biochemical pharmacology, 44(12), 2323-2331 (1992-12-15)
To test the hypothesis of multiplicity in carrier-mediated uptake mechanisms for organic cations in the liver and to study the possible relation with bile acid and cardiac glycoside uptake mechanisms, mutual interaction during uptake of various radiolabeled quaternary amines has
Soon-Sun Hong et al.
Archives of pharmacal research, 29(4), 318-322 (2006-05-10)
Many quaternary ammonium salts are incompletely absorbed after their oral administration and may also be actively secreted into the intestine. However, the underlying mechanism(s) that control the transport of these cations across the intestinal epithelium is not well understood. In
Soon-Sun Hong et al.
Archives of pharmacal research, 29(4), 323-327 (2006-05-10)
The objective of this study was to examine the pharmacokinetics of organic cations in intrahepatic cholestatic rats. A pretreatment with 17alpha-ethynylestradiol was used to induce intrahepatic cholestasis, and tributylmethylammonium (TBuMA) was used as a representative model organic cation. When [3H]TBuMA
Min-Koo Choi et al.
Journal of pharmaceutical sciences, 94(2), 317-326 (2004-12-01)
The in vivo canalicular excretion clearance of tributylmethyl ammonium (TBuMA), a P-glycoprotein (P-gp) substrate, was previously reported to be unaffected by the induction of an experimental hepatic injury (EHI) by CCl(4) despite the increased expression of P-gp in the EHI
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