511412

Ethyl 2-methylindole-3-carboxylate

99%

• Synonym(s): 2-Methylindole-3-carboxylic acid ethyl ester
• Empirical Formula (Hill Notation): C₁₂H₁₃NO₂
• CAS Number: 53855-47-3
• Molecular Weight: 203.24
• MDL number: MFCD01863674
• UNSPSC Code: 12352100
• PubChem Substance ID: 24873445
• NACRES: NA.22

Properties

• assay: 99%
• mp: 134-136 °C (lit.)
• SMILES string: CCOC(=O)c1c(C)[nH]c2ccccc12
• InChI: 1S/C12H13NO2/c1-3-15-12(14)11-8(2)13-10-7-5-4-6-9(10)11/h4-7,13H,3H2,1-2H3
• InChI key: ICXKIKDXKRONLF-UHFFFAOYSA-N

Description

General description

Ethyl 2-methylindole-3-carboxylate is a 2-substituted 1H-indole-3-carboxylate derivative. It can be prepared by reacting 2-iodoaniline with ethyl acetoacetate sodium salt in the presence of copper iodide.

Application

Reactant for preparation of:

• 2-methyl-3-[5-substituted phenyl-1,3,4-oxadiazol-2-yl]-1H-indoles as antimicrobial agents
• Aminoheterocycle via N-amination of heterocyclic compounds with O-benzoylhydroxylamines

Safety Information

• Storage Class: 13 - Non Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)