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510602

Sigma-Aldrich

6-Phenyl-3(2H)-pyridazinone

98%

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About This Item

Empirical Formula (Hill Notation):
C10H8N2O
CAS Number:
2166-31-6
Molecular Weight:
172.18
EC Number:
218-505-1
MDL number:
MFCD00114953
UNSPSC Code:
12352100
PubChem Substance ID:
24873517
NACRES:
NA.22

assay

98%

mp

201-204 °C (lit.)

SMILES string

O=C1NN=C(C=C1)c2ccccc2

InChI

1S/C10H8N2O/c13-10-7-6-9(11-12-10)8-4-2-1-3-5-8/h1-7H,(H,12,13)

InChI key

IJUIPRDMWWBTTQ-UHFFFAOYSA-N

Gene Information

human ... PTPRA(5786)

General description

6-Phenyl-3(2H)-pyridazinone is a pyridazinone derivative that can be prepared from 4,5- dihydro-6-phenyl-3(2H)-pyridazinone.[1] It is reported to be a weak positive inotropic agent.[2] 6-Phenyl-3(2H)-pyridazinone forms the core of compounds that show a potential antiplatelet activity.[1]

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKBL2056V
MKBH3294V
MKBB0758
05828KH
00512CH

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Eddy Sotelo et al.
Bioorganic & medicinal chemistry, 10(9), 2873-2882 (2002-07-12)
A series of 6-phenyl-3(2H)-pyridazinones with a diverse range of substituents in the 5-position have been prepared and evaluated in the search for new antiplatelet agents. A significant dependence of the substituent on the inhibitory effect has been observed. The pharmacological
Cardiotonic agents. 2. Synthesis and structure-activity relationships of 4,5-dihydro-6-[4-(H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones: a new class of positive inotropic agents.
Sircar I, et al.
Journal of Medicinal Chemistry, 28(10), 1405-1413 (1985)

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