47627

Fmoc-Gly-OH

≥98.0% (T)

• Synonym(s): Fmoc-glycine
• Empirical Formula (Hill Notation): C₁₇H₁₅NO₄
• CAS Number: 29022-11-5
• Molecular Weight: 297.31
• Beilstein/REAXYS Number: 2163967
• EC Number: 249-373-3
• MDL number: MFCD00037140
• UNSPSC Code: 12352209
• eCl@ss: 32160406
• PubChem Substance ID: 57651047
• NACRES: NA.26

Properties

• assay: ≥98.0% (T)
• form: powder
• reaction suitability: reaction type: Fmoc solid-phase peptide synthesis
• mp: 174-175 °C (lit.); 174-178 °C
• application(s): peptide synthesis
• functional group: Fmoc
• storage temp.: 2-8°C
• SMILES string: OC(=O)CNC(=O)OCC1c2ccccc2-c3ccccc13
• InChI: 1S/C17H15NO4/c19-16(20)9-18-17(21)22-10-15-13-7-3-1-5-11(13)12-6-2-4-8-14(12)15/h1-8,15H,9-10H2,(H,18,21)(H,19,20)
• InChI key: NDKDFTQNXLHCGO-UHFFFAOYSA-N

Description

Application

• Efficient Fmoc-Protected Amino Ester Hydrolysis Using Green Calcium (II) Iodide as a Protective Agent: This study describes the utilization of environmentally friendly calcium iodide in the hydrolysis of Fmoc-protected amino esters, enhancing reaction efficiency and sustainability (R Binette, M Desgagné, C Theaud, PL Boudreault - Molecules, 2022). Link to the article.
• α/β-Chimera peptide synthesis with cyclic β-sugar amino acids: the efficient coupling protocol: This research provides an advanced synthesis method for α/β-chimera peptides using cyclic β-sugar amino acids, demonstrating significant implications for peptide design in medicinal chemistry (A Nagy, V Goldschmidt Gőz, I Pintér, V Farkas - Amino acids, 2019). Link to the article.
• MS, CD, and FT-IR characterization of five newly synthesized histidine-containing Ala-and Gly-based peptides: This paper presents detailed characterization of novel histidine-containing peptides, highlighting techniques that could be pivotal for peptide-based drug discovery (M Murariu, L Ion, CI Ciobanu, BA Petre - Rev. Roum Chem., 2017). Link to the article.
• Efficient method for the concentration determination of fmoc groups incorporated in the core-shell materials by Fmoc–glycine: This article elaborates on an efficient method for determining the concentration of fmoc groups in core-shell materials, critical for the design of advanced functional materials (E Szczepańska, B Grobelna, J Ryl, A Kulpa - Molecules, 2020). Link to the article.
• Circular aqueous fmoc/t‐bu solid‐phase peptide synthesis: This study explores a novel approach in solid-phase peptide synthesis, utilizing circular aqueous techniques that may offer greener and more efficient methodologies for peptide synthesis (J Pawlas, JH Rasmussen - ChemSusChem, 2021). Link to the article.

Other Notes

Fmoc-glycine coupling of saccharide β-glycosylamines for the fractionation of oligosaccharides and formation of neoglycoconjugates.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)