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466956

Sigma-Aldrich

4-Fluorophenylacetyl chloride

97%

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About This Item

Linear Formula:
FC6H4CH2COCl
CAS Number:
459-04-1
Molecular Weight:
172.58
MDL number:
MFCD00674181
UNSPSC Code:
12352100
PubChem Substance ID:
24870372
NACRES:
NA.22

assay

97%

refractive index

n20/D 1.512 (lit.)

bp

60 °C/8 mmHg (lit.)

density

1.259 g/mL at 25 °C (lit.)

storage temp.

2-8°C

SMILES string

Fc1ccc(CC(Cl)=O)cc1

InChI

1S/C8H6ClFO/c9-8(11)5-6-1-3-7(10)4-2-6/h1-4H,5H2

InChI key

SIOJFYRPBYGHOO-UHFFFAOYSA-N

Application

4-Fluorophenylacetyl chloride may be used in the preparation of bicyclic pyrazolones[1][2] and dihydropyrrol-2-ones.[3]

pictograms

Corrosion
GHS05

signalword

Danger

hcodes

H314

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1B

Storage Class

8A - Combustible corrosive hazardous materials

wgk_germany

WGK 3

flash_point_f

224.6 °F - closed cup

flash_point_c

107 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
MKBF0931V
03407AD
11802AO
10302PU
05515KA

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Development of orally bioavailable bicyclic pyrazolones as inhibitors of tumor necrosis factor-a production.
Clark MP, et al.
Journal of Medicinal Chemistry, 47(11), 2724-2727 (2004)
Drug Des. Discovery, 9, 155-155 (1992)
Drug Des. Discovery, 11, 115-115 (1994)
Convergent synthesis of 2, 3-bisarylpyrazolones through cyclization of bisacylated pyrazolidines and hydrazines.
Brugel TA, et al.
Tetrahedron Letters, 47(19), 3195-3198 (2006)
Synthesis of phenylquinoxaline oligomers containing pendant electron donating and withdrawing groups.
Baek J-B, et al.
Polymer Preprints (American Chemical Society, Division of Polymer Chemistry), 47(1), 341-341 (2006)
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