422886

(S)-(+)-2-(Aminomethyl)pyrrolidine

97%

• Empirical Formula (Hill Notation): C₅H₁₂N₂
• CAS Number: 69500-64-7
• Molecular Weight: 100.16
• MDL number: MFCD00191745
• UNSPSC Code: 12352005
• PubChem Substance ID: 24866461
• NACRES: NA.22

Properties

• assay: 97%
• form: liquid
• optical activity: [α]20/D +20°, c = 1 in chloroform
• refractive index: n20/D 1.482 (lit.)
• bp: 65 °C/11 mmHg (lit.)
• density: 0.933 g/mL at 25 °C (lit.)
• SMILES string: NC[C@@H]1CCCN1
• InChI: 1S/C5H12N2/c6-4-5-2-1-3-7-5/h5,7H,1-4,6H2/t5-/m0/s1
• InChI key: AUKXFNABVHIUAC-YFKPBYRVSA-N

Description

General description

(S)-(+)-2-(Aminomethyl)pyrrolidine is a chiral vicinal diamine.

Application

(S)-(+)-2-(Aminomethyl)pyrrolidine can be used as an organocatalyst:

• For the asymmetric transformation of (S)-alanine.
• In the asymmetric α-fluorination of linear and branched aldehydes using N-fluorobenzenesulfonamide as the fluorinating agent.

It can also be used as a reactant to prepare Schiff base metal complexes with pyrrolidine fragment as a ligand in asymmetric synthesis.

Used in the synthesis of compounds with antitumor activity.

Safety Information

• pictograms: GHS02,GHS07
• signalword: Warning
• hcodes: H226,H315,H319,H335
• pcodes: P210 - P233 - P240 - P241 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 3
• flash_point_f: 116.6 °F - closed cup
• flash_point_c: 47 °C - closed cup
• ppe: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter