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404357

2,4,5-Trifluorobenzoyl chloride

Name: 2,4,5-Trifluorobenzoyl chloride
Brand: ALDRICH

97%

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About This Item

Linear Formula:

F₃C₆H₂COCl

CAS Number:

88419-56-1

Molecular Weight:

194.54

Beilstein/REAXYS Number:

3606259

MDL number:

MFCD00061204

UNSPSC Code:

12352100

PubChem Substance ID:

24865240

NACRES:

NA.22

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assay

97%

form

liquid

refractive index

n20/D 1.498 (lit.)

density

1.52 g/mL at 25 °C (lit.)

SMILES string

Fc1cc(F)c(cc1F)C(Cl)=O

InChI

1S/C7H2ClF3O/c8-7(12)3-1-5(10)6(11)2-4(3)9/h1-2H

InChI key

STBGCAUUOPNJBH-UHFFFAOYSA-N

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General description

2,4,5-Trifluorobenzoyl chloride is an aryl fluorinated building block.

Application

2,4,5-Trifluorobenzoyl chloride may be used in the synthesis of several glycosylated derivatives of some fluoroquinolone antibiotics.[1] It may be employed in one-pot synthesis of ethyl 8,9-difluoro-6-oxo-6H-benzo[c]quinolizine-5-carboxylate.[2]

pictograms

GHS05

signalword

Danger

hcodes

H314

pcodes

P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363 - P405

Hazard Classifications

Skin Corr. 1B

Storage Class

8A - Combustible corrosive hazardous materials

wgk_germany

WGK 3

flash_point_f

186.8 °F - closed cup

flash_point_c

86 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

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The synthesis and biological activity of 8-fluoro-9-(4-methyl-1-piperazinyl)-6-oxo-6H-benzo[c]quinolizine-5-carboxylic acid.

Ziegler B, et al.

Journal of Medicinal Chemistry, 27(3), 587-589 (1990)

Glycosylation of fluoroquinolones through direct and oxygenated polymethylene linkages as a sugar-mediated active transport system for antimicrobials.

M E Jung et al.

Journal of medicinal chemistry, 42(19), 3899-3909 (1999-10-03)

We report herein the synthesis and biological testing of several glycosylated derivatives of some fluoroquinolone antibiotics. In particular, we have prepared several glycosylated derivatives of ciprofloxacin (2) in which the carbohydrate units are linked to the free secondary amine of

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