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402494

Sigma-Aldrich

Phenylarsine oxide

technical grade

Synonym(s):

Arzene, Oxophenylarsine, PAO

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About This Item

Empirical Formula (Hill Notation):
C6H5AsO
CAS Number:
637-03-6
Molecular Weight:
168.02
Beilstein/REAXYS Number:
2935227
EC Number:
211-275-3
MDL number:
MFCD00001990
UNSPSC Code:
12352200
PubChem Substance ID:
329755960

grade

technical grade

reaction suitability

reagent type: catalyst
core: arsenic

SMILES string

O=[As]c1ccccc1

InChI

1S/C6H5AsO/c8-7-6-4-2-1-3-5-6/h1-5H

InChI key

BQVCCPGCDUSGOE-UHFFFAOYSA-N

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Biochem/physiol Actions

Phenylarsine oxide inhibits internalization of cell surface receptors; inhibits tyrosine phosphatases, with no effect on tyrosine kinase. Metabolic poison.

Other Notes

Contains varying amounts of polymer

replaced by

Product No.
Description
Pricing

pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
S43266
71972_
05301TC
19626LO
13612HR

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Shahnaz Shahidi-Noghabi et al.
Archives of insect biochemistry and physiology, 76(4), 211-222 (2011-01-22)
In this project, the uptake mechanisms and localization of two lectins from Sambucus nigra, further referred to as S. nigra agglutinin (SNA)-I and SNA-II, into insect midgut CF-203 cells were studied. SNA-I is a chimeric lectin belonging to the class
Athar Alam et al.
Free radical biology & medicine, 50(11), 1659-1668 (2011-03-17)
Plasmodium falciparum macrophage migration inhibitory factor (PfMIF) exhibits thioredoxin (Trx)-like oxidoreductase activity but the active site for this activity and its function have not been evaluated. A bioinformatics search revealed that the conserved CXXC motif, which is responsible for Trx-like
Anne-Christine Schmidt et al.
Journal of mass spectrometry : JMS, 47(8), 949-961 (2012-08-18)
Phenylarsenic-substituted cysteine-containing peptides and proteins were completely differentiated from their unbound original forms by the coupling of reversed phase liquid chromatography with electrospray ionization mass spectrometry. The analysis of biomolecules possessing structure-stabilizing disulfide bridges after reduction provides new insights into
Biyun Ni et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 18(1), 140-151 (2011-11-04)
Bax and Bak are regarded as key mediators for cytochrome c (Cyt c) release and apoptosis. Loss of Bax or Bak is often reported in human cancers and renders resistance of these cancerous cells to chemotherapy. Here, we investigated that
Marcela de Souza Santos et al.
Molecular pharmacology, 83(4), 793-804 (2013-01-15)
Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) is a versatile phospholipid that participates in many membrane-associated signaling processes. PI(4,5)P2 production at the plasma membrane (PM) depends on levels of its precursor, phosphatidylinositol 4-phosphate (PI4P), synthesized principally by two intracellular enzymes, PI4-kinases IIIα and IIIb;
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