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397210

Sigma-Aldrich

2-Amino-5-chloro-2′-fluorobenzophenone

98%

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About This Item

Linear Formula:
H2NC6H3(Cl)C(O)C6H4F
CAS Number:
Molecular Weight:
249.67
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

assay

98%

mp

95-98 °C (lit.)

SMILES string

Nc1ccc(Cl)cc1C(=O)c2ccccc2F

InChI

1S/C13H9ClFNO/c14-8-5-6-12(16)10(7-8)13(17)9-3-1-2-4-11(9)15/h1-7H,16H2

InChI key

GTGMXPIQRQSORU-UHFFFAOYSA-N

Application

2-Amino-5-chloro-2′-fluorobenzophenone is suitable electrophilic coupling reagent for the determination of iron(III) in environmental waters, soils and industrial effluent samples. It may be used in the synthesis of following:
  • 2,4-disubstituted quinolones, via Meyer-Schuster rearrangement
  • 6-chloro-2-methyl-4-(2-fluorophenyl) quinazoline
  • N-desalkylflurazepam
  • benzotriazepines
  • diazepam-related benzodiazepines.

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


Certificates of Analysis (COA)

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J. Chem. Res. Synop., 2-2 (1991)
Ionic liquid-an efficient recycalable system for the synthesis of 2, 4-disubstituted quinolines via Meyer-Schuster rearrangement.
Saqrma R and Prajapati D.
Synlett, 19, 3001-3005 (2008)
Bhawana Sati et al.
Acta pharmaceutica (Zagreb, Croatia), 63(3), 385-396 (2013-10-25)
During the manufacture of bulk drug midazolam various impurities arised that can be the related products or degradation products. Structures of eight impurities that can arise during the manufacture of bulk drug midazolam were proposed. In the present work, synthesis
Journal of the American Chemical Society, 112, 3969-3969 (1990)

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