374962
4-Guanidinobenzoic acid hydrochloride
99%
Synonym(s):
4-Guanidobenzoic acid hydrochloride
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About This Item
Linear Formula:
H2NC(=NH)NHC6H4CO2H · HCl
CAS Number:
Molecular Weight:
215.64
Beilstein/REAXYS Number:
3718032
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
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assay
99%
form
solid
mp
285 °C (dec.) (lit.)
storage temp.
2-8°C
SMILES string
Cl[H].NC(=N)Nc1ccc(cc1)C(O)=O
InChI
1S/C8H9N3O2.ClH/c9-8(10)11-6-3-1-5(2-4-6)7(12)13;/h1-4H,(H,12,13)(H4,9,10,11);1H
InChI key
YETFLAUJROGBMC-UHFFFAOYSA-N
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General description
4-Guanidinobenzoic acid hydrochloride is a guanidine derivative. Quality standard of 4-guanidinobenzoic acid hydrochloride has been investigated.
Application
4-Guanidinobenzoic acid hydrochloride may be used in ELISA inhibition assay of mouse antiserum.[1] It may be used in the synthesis of human acrosin inhibitor 4′-acetaminophenyl 4-guanidinobenzoate hydrochloride.2
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Hepatic and pancreatic metabolism and biliary excretion of the protease inhibitor camostat mesilate.
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International journal of pancreatology : official journal of the International Association of Pancreatology, 10(3-4), 197-205 (1991-11-01)
The hepatic metabolism and biliary and pancreatic excretion of the serine protease inhibitor camostat mesilate and its metabolites FOY-251 and GBA were studied in rats in vivo and in in sutu liver-perfusion experiments. After oral feeding (100 mg/kg) and iv
K Beckh et al.
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The elimination of the low molecular weight proteinase inhibitor camostate (FOY 305) was studied in rats after oral administration and in the the situ perfused rat liver. After feeding of camostate (400 mg/kg b.w.) only the metabolites (FOY 251, GBA)
G T Layton et al.
Clinical and experimental immunology, 69(1), 157-165 (1987-07-01)
Polyclonal and monoclonal antibodies to the antibacterial agent chlorhexidine (1,1'-hexamethylene bis [5-(p-chlorophenyl)]biguanide, mol. wt = 505) were raised using a chlorine-generated N-chloro chlorhexidine-keyhole limpet haemocyanin (NCC-KLH) conjugate as the immunogen. Antibodies were detected by ELISA, using a semi-chlorhexidine derivative conjugated
Evidence for an enzyme which cleaves the guanidinobenzoate moiety from active-site titrants specifically designed to inhibit and quantify trypsin.
F S Steven et al.
European journal of biochemistry, 130(2), 335-339 (1983-02-01)
S Muto et al.
British journal of pharmacology, 111(1), 173-178 (1994-01-01)
1. The present experiments were undertaken to determine the mechanism(s) of hyperkalaemia caused by nafamostat mesilate (NM), a serine-protease inhibitor. 2. We investigated the effects of luminal addition of two metabolites of NM, p-guanidinobenzoic acid (PGBA) and 6-amidino-2-naphthol (AN), on
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