374717

Triethyl 2-fluoro-2-phosphonoacetate

96%

• Synonym(s): 2-Fluoro-2-phosphonoacetic acid triethyl ester, Diethyl [(ethoxycarbonyl)fluoromethyl]phosphonate, Ethyl diethylphosphonofluoroacetate
• Linear Formula: (C₂H₅O)₂P(O)CH(F)CO₂C₂H₅
• CAS Number: 2356-16-3
• Molecular Weight: 242.18
• Beilstein/REAXYS Number: 1912161
• MDL number: MFCD00134400
• UNSPSC Code: 12352108
• PubChem Substance ID: 24863330
• NACRES: NA.22

Properties

• assay: 96%
• form: liquid
• reaction suitability: reaction type: C-C Bond Formation
• refractive index: n20/D 1.425 (lit.)
• bp: 75 °C/0.01 mmHg (lit.)
• density: 1.194 g/mL at 25 °C (lit.)
• SMILES string: CCOC(=O)C(F)P(=O)(OCC)OCC
• InChI: 1S/C8H16FO5P/c1-4-12-8(10)7(9)15(11,13-5-2)14-6-3/h7H,4-6H2,1-3H3
• InChI key: FVPISMANESAJQZ-UHFFFAOYSA-N

Description

Application

Reactant for:

• Diels-Alder reactions
• Biosynthesis of terpene
• Stereoselective synthesis of unsaturated esters, fluorides and nitriles from the reactions of aldehydes and ketones using Wadsworth-Emmons phosphonates
• Synthesis of quinolones
• Horner-Wadsworth-Emmons asymmetric hydration
• Addition reactions and the subsequent application to click chemistry
• Asymmetric intermolecular Stetter reactions

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 3
• flash_point_f: 163.4 °F - closed cup
• flash_point_c: 73 °C - closed cup
• ppe: Eyeshields, Gloves, type ABEK (EN14387) respirator filter