360236
1-Methyluric acid
99%
Synonym(s):
1-Methyl-2,6,8-trihydroxypurine, 1-U, 1MUA
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About This Item
Empirical Formula (Hill Notation):
C6H6N4O3
CAS Number:
Molecular Weight:
182.14
Beilstein/REAXYS Number:
195190
EC Number:
MDL number:
UNSPSC Code:
12352200
assay
99%
SMILES string
CN1C(=O)NC2=C(NC(=O)N2)C1=O
InChI
1S/C6H6N4O3/c1-10-4(11)2-3(9-6(10)13)8-5(12)7-2/h1H3,(H,9,13)(H2,7,8,12)
InChI key
QFDRTQONISXGJA-UHFFFAOYSA-N
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Boris Rocić et al.
Bioorganic & medicinal chemistry letters, 15(4), 1181-1184 (2005-02-03)
Uric acid (1a) suppresses basal insulin release in isolated rat pancreatic islets and inhibition of glucose-stimulated insulin secretion (GSIS) occurs right at hyperuricaemic levels (0.4 mM). Conversely, 1 mM guanidinium urate (2a) was completely ineffective, strongly suggesting that binding to
Alexander C Roy et al.
Bioorganic & medicinal chemistry letters, 20(1), 141-144 (2009-12-17)
CTP synthase (CTPS) catalyzes the conversion of UTP to CTP and is a recognized target for the development of anticancer, antiviral, and antiprotozoal agents. Xanthine and related compounds inhibit CTPS activity (IC(50)=0.16-0.58mM). The presence of an 8-oxo function (i.e., uric
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