344591

2,3,5,6-Tetrafluoro-4-pyridinecarbonitrile

99%

• Empirical Formula (Hill Notation): C₆F₄N₂
• CAS Number: 16297-07-7
• Molecular Weight: 176.07
• MDL number: MFCD00075302
• UNSPSC Code: 12352100
• PubChem Substance ID: 24861263
• NACRES: NA.22

Properties

• assay: 99%
• form: solid
• mp: 66-68 °C (lit.)
• functional group: fluoro; nitrile
• SMILES string: Fc1nc(F)c(F)c(C#N)c1F
• InChI: 1S/C6F4N2/c7-3-2(1-11)4(8)6(10)12-5(3)9
• InChI key: JXISJBVJNUKKBK-UHFFFAOYSA-N

Description

General description

2,3,5,6-Tetrafluoro-4-pyridinecarbonitrile is a perfluorinated heteroaromatic compound. 2,3,5,6-Tetrafluoro-4-pyridinecarbonitrile (tetrafluoro-4-cyanopyridine) reacts with 1,3-dicarbonyl systems to yield the corresponding [5,6]-ring fused furo derivatives. 2,3,5,6-Tetrafluoro-4-pyridinecarbonitrile (4-cyanotetrafluoropyridine) reacts with amidines to yield [6,6]-fused pyrimidinopyridine system via nucleophilic substitution at the C-3 position of the pyridine ring followed by intramolecular cyclization onto the pendant cyano group. Reaction of 2,3,5,6-tetrafluoro-4-pyridinecarbonitrile (4-cyanotetrafluoropyridine) with sulfur centred nucleophiles has been reported.

Application

2,3,5,6-Tetrafluoro-4-pyridinecarbonitrile may be used in the preparation of 2-anilino-3,5,6-trifluoroisonicotinonitrile.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302 + H312 + H332,H315,H319,H335
• pcodes: P261 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves