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Sigma-Aldrich

4-Chloro-2,8-bis(trifluoromethyl)quinoline

97%

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About This Item

Empirical Formula (Hill Notation):
C11H4ClF6N
CAS Number:
83012-13-9
Molecular Weight:
299.60
EC Number:
280-132-5
MDL number:
MFCD00075104
UNSPSC Code:
12352100
PubChem Substance ID:
24860490

assay

97%

mp

46-48 °C (lit.)

functional group

chloro
fluoro

SMILES string

FC(F)(F)c1cc(Cl)c2cccc(c2n1)C(F)(F)F

InChI

1S/C11H4ClF6N/c12-7-4-8(11(16,17)18)19-9-5(7)2-1-3-6(9)10(13,14)15/h1-4H

InChI key

ZSQOESPYYNJBCZ-UHFFFAOYSA-N

General description

4-Chloro-2,8-bis(trifluoromethyl)quinolone is the intermediate formed during the synthesis of quinoline derivatives.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

235.4 °F - closed cup

flash_point_c

113 °C - closed cup

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
13404CZ

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Sumesh Eswaran et al.
European journal of medicinal chemistry, 45(8), 3374-3383 (2010-06-12)
Four new series of quinoline derivatives were synthesized starting from 2-trifluoromethyl aniline through multi-step reactions. In the reaction sequence, substituted aniline was cyclized to 4-hydroxy quinoline 1, which was then transformed to 4-chloro-2,8-bis(trifluoromethyl)quinoline 2. The key scaffold 4-hydrazinyl-2,8-bis(trifluoromethyl)quinoline 3, obtained

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