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Key Documents

286990

Sigma-Aldrich

Prednisone

98%

Synonym(s):

1,4-Pregnadiene-17α,21-diol-3,11,20-trione, 1-Cortisone, 17α,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione, Dehydrocortisone

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About This Item

Empirical Formula (Hill Notation):
C21H26O5
CAS Number:
Molecular Weight:
358.43
Beilstein/REAXYS Number:
2065301
EC Number:
MDL number:
UNSPSC Code:
12352200

assay

98%

optical activity

[α]25/D +169°, c = 0.5 in dioxane

mp

236-238 °C (lit.)

SMILES string

O=C1C=C[C@@]2(C)C(CC[C@]([C@@](CC[C@@]3(C(CO)=O)O)([H])[C@]3(C)C4)([H])[C@]2([H])C4=O)=C1

InChI

1S/C21H26O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-15,18,22,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1

InChI key

XOFYZVNMUHMLCC-ZPOLXVRWSA-N

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pictograms

Health hazard

signalword

Warning

hcodes

Hazard Classifications

STOT RE 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges


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Suzana Jordan et al.
Annals of the rheumatic diseases, 74(6), 1188-1194 (2014-01-21)
To assess the effects of Rituximab (RTX) on skin and lung fibrosis in patients with systemic sclerosis (SSc) belonging to the European Scleroderma Trial and Research (EUSTAR) cohort and using a nested case-control design. Inclusion criteria were fulfilment of American
Gerard J Criner et al.
Chest, 147(4), 894-942 (2014-10-17)
COPD is a major cause of morbidity and mortality in the United States as well as throughout the rest of the world. An exacerbation of COPD (periodic escalations of symptoms of cough, dyspnea, and sputum production) is a major contributor
Chris S Earl et al.
EMBO molecular medicine, 7(8), 1018-1033 (2015-05-23)
Glucocorticosteroids are used as a main treatment to reduce airway inflammation in people with asthma who suffer from neutrophilic airway inflammation, a condition frequently associated with Haemophilus influenzae colonization. Here we show that glucocorticosteroids have a direct influence on the
Ian F Tannock et al.
The Lancet. Oncology, 14(8), 760-768 (2013-06-08)
Docetaxel plus prednisone is standard first-line chemotherapy for men with metastatic castrate-resistant prostate cancer. Aflibercept is a recombinant human fusion protein that binds A and B isoforms of VEGF and placental growth factor, thereby inhibiting angiogenesis. We assessed whether the
Jörg D Leuppi et al.
JAMA, 309(21), 2223-2231 (2013-05-23)
International guidelines advocate a 7- to 14-day course of systemic glucocorticoid therapy in acute exacerbations of chronic obstructive pulmonary disease (COPD). However, the optimal dose and duration are unknown. To investigate whether a short-term (5 days) systemic glucocorticoid treatment in

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