This product is certainly not for human use. It is labeled "For R&D Use Only". It is not tested for toxicity or effectiveness in any biological system, in vitro or in vivo. The specification sheet shows that only chemical testing is done on it: https://www.sigmaaldrich.com/specification-sheet/ALDRICH/286044
286044
Harmine
98%
Synonym(s):
7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole
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1 G
$135.00
About This Item
Empirical Formula (Hill Notation):
C13H12N2O
CAS Number:
Molecular Weight:
212.25
Beilstein/REAXYS Number:
178813
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
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assay
98%
mp
262-264 °C (lit.)
SMILES string
CC1=NC=CC2=C1NC3=C2C=CC(OC)=C3
InChI
1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3
InChI key
BXNJHAXVSOCGBA-UHFFFAOYSA-N
Gene Information
human ... CDC2(983) , CYP2D6(1565)
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General description
The combination index (CI, serves as a quantitative indicator of pharmacological interactions) for harmaline/harmine and methylene blue/harmine was studied[1].
Application
Harmine was used as a donor in the fluorescence resonance energy transfer (FRET) study between harmine and silver nanoparticles (AgNPs)[2].
Biochem/physiol Actions
Central nervous system stimulant.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Katie L Uhl et al.
Cancer cell international, 18, 82-82 (2018-07-07)
Neuroblastoma (NB) is an early childhood malignancy that arises from the developing sympathetic nervous system. Harmine is a tricyclic β-carboline alkaloid isolated from the harmal plant that exhibits both cytostatic and cytotoxic effects. Harmine is capable of blocking the activities
Michael F Santillo et al.
Toxicology in vitro : an international journal published in association with BIBRA, 28(3), 403-410 (2014-01-01)
Interactions among monoamine oxidase (MAO) inhibitors in drugs, botanicals, and dietary supplements may lead to unpredictable neurochemical dysfunction due to excessive inhibition or therapeutic invalidation. Often recombinant MAO or brain tissue homogenates have been used to evaluate MAO inhibitors such
Raphaël Frédérick et al.
Journal of medicinal chemistry, 55(14), 6489-6501 (2012-07-10)
To overcome the intrinsic resistance of cancer cells to apoptotic stimuli, we designed and synthesized approximately 50 novel β-carbolines structurally related to harmine. Harmine is known for its anticancer properties and is a DYRK1A inhibitor. Of the synthesized compounds, the
Mohammad Amjadi et al.
Luminescence : the journal of biological and chemical luminescence, 29(6), 689-694 (2013-11-30)
This article reports on a novel fluorescence resonance energy transfer (FRET) system between harmine and silver nanoparticles (AgNPs), in which harmine acts as the donor and AgNPs act as the acceptor. As a result of FRET, harmine fluorescence is quenched
Mansour Debdab et al.
Journal of medicinal chemistry, 54(12), 4172-4186 (2011-05-28)
We here report on the synthesis, optimization, and biological characterization of leucettines, a family of kinase inhibitors derived from the marine sponge leucettamine B. Stepwise synthesis of analogues starting from the natural structure, guided by activity testing on eight purified
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I want to use harmine to try to reproduce my beta cells, it is safe to inject it? will cause any damage?
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