242934

Ethyl iodoacetate

98%

• Synonym(s): Ethyl 2-iodoacetate, Ethyl monoiodoacetate, Iodoacetic acid ethyl ester
• Linear Formula: ICH₂COOC₂H₅
• CAS Number: 623-48-3
• Molecular Weight: 214.00
• Beilstein/REAXYS Number: 741934
• EC Number: 210-796-3
• MDL number: MFCD00001081
• UNSPSC Code: 12352100
• PubChem Substance ID: 24854592
• NACRES: NA.22

Properties

• Quality Level: 200
• assay: 98%
• refractive index: n20/D 1.503 (lit.)
• bp: 179-180 °C (lit.)
• density: 1.808 g/mL at 25 °C (lit.)
• functional group: ester; iodo
• storage temp.: 2-8°C
• SMILES string: CCOC(=O)CI
• InChI: 1S/C4H7IO2/c1-2-7-4(6)3-5/h2-3H2,1H3
• InChI key: MFFXVVHUKRKXCI-UHFFFAOYSA-N

Description

General description

Ethyl iodoacetate, also known as iodoacetic acid ethyl ester, serves as an alkylating agent and a radical precursor in organic synthesis. It is also commonly used as a lachrymatory agent. [1]

Application

Ethyl iodoacetate was used in the synthesis of trans-2,3-disubstituted indolines by reacting with 1-azido-2-allylbenzene derivatives via a diastereoselective radical cascade[2].

Safety Information

• pictograms: GHS06,GHS05
• signalword: Danger
• hcodes: H300,H314
• pcodes: P280 - P301 + P310 + P330 - P301 + P330 + P331 - P303 + P361 + P353 - P305 + P351 + P338 + P310
• Hazard Classifications: Acute Tox. 2 Oral - Eye Dam. 1 - Skin Corr. 1B
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk_germany: WGK 3
• flash_point_f: 170.6 °F - closed cup
• flash_point_c: 77 °C - closed cup
• ppe: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter