230235

Diphenylphosphinic chloride

98%

• Synonym(s): Diphenylchlorophosphine oxide, Diphenylphosphinic acid chloride, Diphenylphosphinoyl chloride, Diphenylphosphinyl chloride, Diphenylphosphorus oxychloride, Ph₂POCl, Chlorodiphenylphosphine oxide
• Linear Formula: (C₆H₅)₂P(O)Cl
• CAS Number: 1499-21-4
• Molecular Weight: 236.63
• Beilstein/REAXYS Number: 975191
• EC Number: 216-107-2
• MDL number: MFCD00002077
• UNSPSC Code: 12352002
• PubChem Substance ID: 24853787
• NACRES: NA.22

Properties

• Quality Level: 100
• assay: 98%
• form: liquid
• reaction suitability: reaction type: Buchwald-Hartwig Cross Coupling Reaction; reaction type: Heck Reaction; reaction type: Hiyama Coupling; reaction type: Negishi Coupling; reaction type: Sonogashira Coupling; reaction type: Stille Coupling; reaction type: Suzuki-Miyaura Coupling
• refractive index: n20/D 1.609 (lit.)
• bp: 222 °C/16 mmHg (lit.)
• density: 1.24 g/mL at 25 °C (lit.)
• storage temp.: 2-8°C
• SMILES string: ClP(=O)(c1ccccc1)c2ccccc2
• InChI: 1S/C12H10ClOP/c13-15(14,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H
• InChI key: QPQGTZMAQRXCJW-UHFFFAOYSA-N

Description

Application

Diphenylphosphinic chloride (Ph₂POCl) is widely used as a precursor to synthesize various chiral phosphine bidentate ligands for asymmetric synthesis, in addition to several peptide coupling agents.

Safety Information

• pictograms: GHS02,GHS05,GHS07
• signalword: Danger
• hcodes: H226,H314,H317
• pcodes: P210 - P233 - P240 - P280 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1B - Skin Sens. 1A
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 3
• flash_point_f: 78.8 °F - closed cup
• flash_point_c: 26 °C - closed cup
• ppe: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter