228028
1,8-Naphthosultam
97%
Synonym(s):
1,8-Naphthalenesultam
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About This Item
Empirical Formula (Hill Notation):
C10H7NO2S
CAS Number:
Molecular Weight:
205.23
Beilstein/REAXYS Number:
83801
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
assay
97%
form
solid
mp
173-175 °C (lit.)
SMILES string
O=S1(=O)Nc2cccc3cccc1c23
InChI
1S/C10H7NO2S/c12-14(13)9-6-2-4-7-3-1-5-8(11-14)10(7)9/h1-6,11H
InChI key
HOBYPSNNFBRLIX-UHFFFAOYSA-N
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General description
1,8-Naphthosultamyl group is a novel PBP2a (penicillin-binding protein 2a)-binding, anti-methicillin-resistant Staphylococcus aureus (MRSA) pharmacophore[1].
Storage Class
13 - Non Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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R R Wilkening et al.
Bioorganic & medicinal chemistry letters, 9(5), 673-678 (1999-04-14)
A series of 1beta-methyl carbapenems substituted at the 2-position with lipophilic, acyclic and cyclic (sulfonamido)methyl groups was prepared and evaluated for activity against resistant gram-positive bacteria. From these studies, the 1,8-naphthosultamyl group emerged as a novel, PBP2a-binding, anti-MRSA pharmacophore worthy
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