225525
2-Amino-2-norbornanecarboxylic acid
98%
Synonym(s):
2-Aminobicyclo[2.2.1]heptane-2-carboxylic acid
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About This Item
Empirical Formula (Hill Notation):
C8H13NO2
CAS Number:
Molecular Weight:
155.19
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
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assay
98%
mp
>300 °C (lit.)
SMILES string
NC1(C[C@@H]2CC[C@H]1C2)C(O)=O
InChI
1S/C8H13NO2/c9-8(7(10)11)4-5-1-2-6(8)3-5/h5-6H,1-4,9H2,(H,10,11)/t5-,6+,8?/m1/s1
InChI key
MPUVBVXDFRDIPT-RSHNMJPRSA-N
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Ashwini L Chand et al.
Human reproduction (Oxford, England), 26(11), 3102-3108 (2011-09-15)
Little is known about metabolic processes in the developing ovarian follicle. Using mouse ovarian follicles, we investigated uptake of L-leucine by follicles at varying stages of maturity in the presence of insulin-like growth factor (IGF)-1. METHODS Mouse ovarian follicles were
Laura J Brown et al.
The Journal of biological chemistry, 284(51), 35359-35367 (2009-10-28)
The cytosolic malic enzyme (ME1) has been suggested to augment insulin secretion via the malate-pyruvate and/or citrate-pyruvate shuttles, through the production of NADPH or other metabolites. We used selectable vectors expressing short hairpin RNA (shRNA) to stably decrease Me1 mRNA
Jordan A Torok et al.
American journal of respiratory cell and molecular biology, 47(1), 37-43 (2012-02-11)
Inhaled nitric oxide (iNO) is used to treat pulmonary hypertension and is being investigated for prevention of bronchopulmonary dysplasia in neonates. Extrapulmonary effects of iNO are widely recognized, but the underlying chemistry and pharmacology are poorly understood. Growing evidence suggests
Seung Jin Han et al.
The Journal of endocrinology, 212(3), 307-315 (2011-12-02)
2-Aminobicyclo-(2,2,1)-heptane-2-carboxylic acid (BCH) is an activator of glutamate dehydrogenase (GDH), which is a mitochondrial enzyme with an important role in insulin secretion. We investigated the effect of BCH on the high-glucose (HG)-induced reduction in glucose-stimulated insulin secretion (GSIS), the HG/palmitate
Mikko Gynther et al.
Journal of medicinal chemistry, 51(4), 932-936 (2008-01-26)
The blood-brain barrier efficiently controls the entry of drug molecules into the brain. We describe a feasible means to achieve carrier-mediated drug transport into the rat brain via the specific, large neutral amino acid transporter (LAT1) by conjugating a model
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