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220604

Sigma-Aldrich

2-Methyl-9-acridinecarboxaldehyde

97%

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About This Item

Empirical Formula (Hill Notation):
C15H11NO
CAS Number:
70401-29-5
Molecular Weight:
221.25
EC Number:
274-594-7
MDL number:
MFCD00005031
UNSPSC Code:
12352100
PubChem Substance ID:
24853182
NACRES:
NA.22

assay

97%

form

solid

mp

145-146 °C (lit.)

SMILES string

[H]C(=O)c1c2ccccc2nc3ccc(C)cc13

InChI

1S/C15H11NO/c1-10-6-7-15-12(8-10)13(9-17)11-4-2-3-5-14(11)16-15/h2-9H,1H3

InChI key

PIBZGMVFXCKDER-UHFFFAOYSA-N

Application

2-Methyl-9-acridinecarboxaldehyde was used:
  • in cleavage assay of rRNA by denaturing gel electrophoresis
  • in the synthesis of peptide-acridine/acridone conjugates, potential anticancer, antiviral and antiprion drugs

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
04615BE
7614PE

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M Kukowska-Kaszuba et al.
Current medicinal chemistry, 14(29), 3079-3104 (2008-01-29)
This paper consists in information about structure, synthesis and biological activity of peptide-acridine/acridone conjugates which are potential anticancer, antiviral and antiprion drugs.
C H Tung et al.
Proceedings of the National Academy of Sciences of the United States of America, 89(15), 7114-7118 (1992-08-01)
A series of peptide-acridine conjugates was designed and synthesized, based on three features of the proposed catalytic mechanism of RNase A: 2'-proton abstraction by His-12, proton donation to the leaving 5'-oxygen by His-119, and stabilization of the pentacoordinated phosphorous transition

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