Arsenic(III) chloride can be used as a precursor to synthesize As-based nanocrystal alloys for thermoelectric materials and biarsenical ligands protein labeling.
Although mechanisms of arsenic trioxide (As(2)O(3))-induced cell death have been studied extensively in hematologic cancers, those in solid cancers have yet to be clearly defined. In this study, we showed that the translocation of apoptosis-inducing factor (AIF) from mitochondria to
The Journal of pharmacology and experimental therapeutics, 332(1), 66-75 (2009-10-08)
Arsenic activates nuclear factor erythroid 2-related factor 2 (Nrf2) to induce phase II and antioxidative genes. Here we analyzed arsenic-Kelch-like ECH-associated protein 1 (Keap1) cysteine thiol interaction in Nrf2 activation. Arsenic-based Nrf2 activators, fluorescent biarsenical labeling reagent (FlAsH) and phenylarsine
Zhongguo shi yan xue ye xue za zhi, 13(5), 778-782 (2005-11-10)
To explore the effects of vascular endothelial growth factor (VEGF) on the mechanisms of CML pathogenesis, the effect of VEGF on K562 cell apoptosis induced by As(2)O(3) was analyzed through morphologic observation, DNA fragmentation agarose gel electrophoresis and DNA ploidy
Gan to kagaku ryoho. Cancer & chemotherapy, 29 Suppl 1, 214-218 (2002-03-14)
Treatment of APL with ATRA or As2O3 alone or in combination with chemotherapy yields a complete remission as high as 85%-95%, but their mechanisms of action remain unclear. The mechanisms of action underlying ATRA treatment are (1) relocalization of the
World journal of gastroenterology, 13(48), 6498-6505 (2007-12-29)
To investigate the effect of arsenic trioxide (As2O3) on expression of vascular endothelial growth factor receptor-1 (VEGFR-1, Flt-1) and VEGFR-2 (KDR) in human gastric tumor cells and proliferation of vascular endothelial cells. The solid tumor model was formed in nude
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