Skip to Content
MilliporeSigma
All Photos(1)

Documents

196622

Sigma-Aldrich

2,5-Difluoronitrobenzene

97%

Synonym(s):

1,4-Difluoro-2-nitrobenzene

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Linear Formula:
F2C6H3NO2
CAS Number:
364-74-9
Molecular Weight:
159.09
EC Number:
206-663-4
MDL number:
MFCD00007054
UNSPSC Code:
12352100
PubChem Substance ID:
24851776
NACRES:
NA.22

assay

97%

form

liquid

refractive index

n20/D 1.509 (lit.)

bp

206.5 °C (lit.)

mp

−11.7 °C (lit.)

density

1.467 g/mL at 25 °C (lit.)

SMILES string

[O-][N+](=O)c1cc(F)ccc1F

InChI

1S/C6H3F2NO2/c7-4-1-2-5(8)6(3-4)9(10)11/h1-3H

InChI key

XNJAYQHWXYJBBD-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Related Categories

Application

2,5-Difluoronitrobenzene was used in the synthesis of :
  • N-alkylated 2-arylaminobenzimidazoles
  • quinoxalinones
  • N-(2-nitro-4-fluorophenyl)-l,2,3,4-tetrahydroisoquinoline

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

194.0 °F - closed cup

flash_point_c

90 °C - closed cup

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

H E Haenen et al.
Chemico-biological interactions, 98(2), 97-112 (1995-11-17)
Proximal tubular biotransformation of the glutathionyl (GSH) conjugate derived from 2,5-difluoronitrobenzene (5-fluoro-2-glutathionyl-nitrobenzene) was studied by means of 19F-NMR. This method allows a direct and specific detection of the fluorinated metabolites formed, at a detection limit of 1 microM for an
Ring-opening reactions of N-aryl-, 1, 2, 3, 4-tetrahydroisoquinoline derivatives.
Andrew HK and Stanforth SP.
Tetrahedron, 48(4), 743-750 (1992)
A solid phase traceless synthesis of quinoxalinones.
Krchnak V, et al.
Tetrahedron Letters, 41(16), 2835-2838 (2000)
I M Rietjens et al.
Chemico-biological interactions, 94(1), 49-72 (1995-01-01)
The in vivo metabolite patterns of 2,5-difluoroaminobenzene and of its nitrobenzene analogue, 2,5-difluoronitrobenzene, were determined using 19F NMR analysis of urine samples. Results obtained demonstrate significant differences between the biotransformation patterns of these two analogues. For the aminobenzene, cytochrome P450
Manuel A V Ribeiro da Silva et al.
The journal of physical chemistry. B, 114(40), 12914-12925 (2010-09-24)
This work reports the experimental and computational thermochemical study performed on three difluorinated nitrobenzene isomers: 2,4-difluoronitrobenzene (2,4-DFNB), 2,5-difluoronitrobenzene (2,5-DFNB), and 3,4-difluoronitrobenzene (3,4-DFNB). The standard (p° = 0.1 MPa) molar enthalpies of formation in the liquid phase of these compounds were
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service