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Key Documents

194484

Sigma-Aldrich

O-(2,3,4,5,6-Pentafluorobenzyl)hydroxylamine hydrochloride

≥98%

Synonym(s):

PFBHA·HCl

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About This Item

Linear Formula:
C6F5CH2ONH2·HCl
CAS Number:
Molecular Weight:
249.57
Beilstein/REAXYS Number:
4031190
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

assay

≥98%

form

solid

mp

227 °C (subl.) (lit.)

solubility

water: soluble 50 mg/mL, clear to slightly hazy, colorless

functional group

fluoro

SMILES string

Cl.NOCc1c(F)c(F)c(F)c(F)c1F

InChI

1S/C7H4F5NO.ClH/c8-3-2(1-14-13)4(9)6(11)7(12)5(3)10;/h1,13H2;1H

InChI key

HVMVKNXIMUCYJA-UHFFFAOYSA-N

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Application

O-(2,3,4,5,6-Pentafluorobenzyl)hydroxylamine hydrochloride is used:
  • In the preparation of oximes of steroids-bearing keto group.
  • As a derivatization reagent in the determination of thromboxane B2, prostaglandins, amygdalin, and a variety of aldehydes, ketones, and acids.
It is a versatile reagent used for the detection of carbonyl-containing compounds by GC, GC-MS, and other methods.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Raya Ahmed et al.
Cell reports, 33(11), 108501-108501 (2020-12-17)
A central paradigm in the field of lymphocyte biology asserts that replicatively senescent memory T cells express the carbohydrate epitope CD57. These cells nonetheless accumulate with age and expand numerically in response to persistent antigenic stimulation. Here, we use in vivo deuterium
Vicente Ferreira et al.
Journal of chromatography. A, 1122(1-2), 255-265 (2006-05-20)
This work presents a thorough study of some aspects critical to the quantitative performance of methods for the determination of volatile aldehydes previously derivatized to pentafluorobenzyl hydroxylamine oximes. The conclusions of the study are further applied to the validation of
Chunhui Deng et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 810(2), 269-275 (2004-09-24)
Analysis of breath acetone has been used as a diagnostic tool for diabetes. Due to its nature of volatility and activity, it is very difficult to accurately measure the concentration of acetone in human breath by gas chromatography-mass spectrometry (GC-MS).
R S Spaulding et al.
Analytical and bioanalytical chemistry, 372(7-8), 808-816 (2002-05-16)
The employment of O-(2,3,4,5,6-pentafluorobenzyl)hydroxylamine (PFBHA) derivatization along with bis-(trimethylsilyl)trifluoroacetamide (BSTFA) or N, N-( tert-butyldimethylsilyl)trifluoroacetamide (MTBSTFA) derivatization is a popular method for measurement of oxygenated organics in environmental and biological samples. Most notably, the derivatization method enables the measurement of atmospheric
S W Liou et al.
Bulletin of environmental contamination and toxicology, 80(4), 324-328 (2008-03-18)
This work studied the feasibility of using a solid phase microextraction (SPME) fiber for sampling and analysis of gaseous formaldehyde as well as particulate-bound formaldehyde from burning Chinese incense. The SPME fiber with PDMS/DVB coating were partially coated with o-(2,3,4,5,6-pentafluorobenzyl)-hydroxylamine

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