191736
Pargyline hydrochloride
99%
Synonym(s):
N-Methyl-N-(2-propynyl)benzylamine hydrochloride, N-Methyl-N-propargylbenzylamine hydrochloride
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About This Item
Linear Formula:
C6H5CH2N(CH3)CH2C≡CH·HCl
CAS Number:
Molecular Weight:
195.69
Beilstein/REAXYS Number:
3699487
EC Number:
MDL number:
UNSPSC Code:
12352103
PubChem Substance ID:
assay
99%
mp
160-163 °C (lit.)
SMILES string
Cl[H].CN(CC#C)Cc1ccccc1
InChI
1S/C11H13N.ClH/c1-3-9-12(2)10-11-7-5-4-6-8-11;/h1,4-8H,9-10H2,2H3;1H
Inchi Key
BCXCABRDBBWWGY-UHFFFAOYSA-N
Gene Information
human ... MAOA(4128) , MAOB(4129)
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Biochem/physiol Actions
Selective MAO-B inhibitor.
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15N magnetic resonance hyperpolarization via the reaction of parahydrogen with 15N-propargylcholine.
Francesca Reineri et al.
Journal of the American Chemical Society, 134(27), 11146-11152 (2012-06-06)
(15)N-Propargylcholine has been synthesized and hydrogenated with para-H(2). Through the application of a field cycling procedure, parahydrogen spin order is transferred to the (15)N resonance. Among the different isomers formed upon hydrogenation of (15)N-propargylcholine, only the nontransposed derivative contributes to
Masahiro Yoshida et al.
The Journal of organic chemistry, 78(4), 1687-1692 (2013-02-01)
The reaction of propargylic carbonates with 4-hydroxy-2-pyrones in the presence of a palladium catalyst is described. By the choice of the reaction temperature, two types of the substituted furo[3,2-c]pyran-4-one derivatives were regioselectively synthesized, respectively.
Lavinia Boccia et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(11), 15448-15461 (2020-09-29)
The LPBN (lateral parabrachial nucleus) plays an important role in feeding control. CGRP (calcitonin gene-related peptide) LPBN neurons activation mediates the anorectic effects of different gut-derived peptides, including amylin. Amylin and its long acting analog sCT (salmon calcitonin) exert their
Shauna N Vasilatos et al.
Carcinogenesis, 34(6), 1196-1207 (2013-01-29)
Our previous studies demonstrated that lysine-specific demethylase 1 (LSD1) and histone deacetylases (HDACs) closely interact in controlling growth of breast cancer cells. However, the underlying mechanisms are largely unknown. In this study, we showed that knockdown of LSD1 expression (LSD1-KD)
Zheng Jiang et al.
Organic letters, 14(24), 6266-6269 (2012-12-01)
An efficient and straightforward strategy for the synthesis of tetrasubstituted imidazoles from propargyl amines, sulfonyl azides, and terminal alkynes is described. N-sulfonyl ketenimine and aminoallene are believed to be the key intermediates for this two-step one-pot transformation.
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