174602

Phenyl N-phenylphosphoramidochloridate

≥99%

• Synonym(s): N-Phenylphosphoramidochloridic acid phenyl ester
• Linear Formula: C₆H₅NHP(O)(Cl)OC₆H₅
• CAS Number: 51766-21-3
• Molecular Weight: 267.65
• EC Number: 257-400-5
• MDL number: MFCD00003029
• UNSPSC Code: 12352002
• PubChem Substance ID: 24850351
• NACRES: NA.22

Properties

• assay: ≥99%
• form: solid
• reaction suitability: reaction type: Buchwald-Hartwig Cross Coupling Reaction; reaction type: Heck Reaction; reaction type: Hiyama Coupling; reaction type: Negishi Coupling; reaction type: Sonogashira Coupling; reaction type: Stille Coupling; reaction type: Suzuki-Miyaura Coupling
• mp: 132-134 °C (lit.)
• SMILES string: ClP(=O)(Nc1ccccc1)Oc2ccccc2
• InChI: 1S/C12H11ClNO2P/c13-17(15,14-11-7-3-1-4-8-11)16-12-9-5-2-6-10-12/h1-10H,(H,14,15)
• InChI key: ZUQYQPGYEFBITH-UHFFFAOYSA-N

Description

Application

Reactant for synthesis of:

• Resin-immobilized actinide ligands
• Carboxylic acid anhydrides and their derivatives
• Thiadiaminooxopyrimidine derivatives for antitumor activity
• Polyanhydrides via dehydrative coupling agents

Reactant for:

• One-pot conversion of pyrimidinones to pyrimidines
• Conversion to alkyl Ph diester

Catalyst for polymerization reactions

Involved in biological studies for chymotrypsin binding and inhibition

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves