161136
3-Hydroxytyramine hydrobromide
99%
Synonym(s):
3,4-Dihydroxyphenethylamine hydrobromide, Dopamine hydrobromide
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About This Item
Linear Formula:
(HO)2C6H3CH2CH2NH2·HBr
CAS Number:
Molecular Weight:
234.09
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
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assay
99%
form
solid
mp
218-220 °C (lit.)
SMILES string
Br.NCCc1ccc(O)c(O)c1
InChI
1S/C8H11NO2.BrH/c9-4-3-6-1-2-7(10)8(11)5-6;/h1-2,5,10-11H,3-4,9H2;1H
InChI key
SGRSNYSOAPBTJP-UHFFFAOYSA-N
Application
3-Hydroxytyramine hydrobromide was used in the preparation of dopamine standards to measure the dopamine release and uptake in striatal brain slices from R6/1 HD model mice by fast-scan cyclic voltammetry.[1] It was employed as internal standard in the determination of catecholamines in biological tissues by liquid chromatography.[2]
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Determination of catecholamines in biological tissues by liquid chromatography with coulometric detection.
G de Saint Blanquat et al.
Journal of chromatography, 415(2), 388-392 (1987-04-10)
Andrea N Ortiz et al.
Neuroscience letters, 492(1), 11-14 (2011-01-25)
Huntington's disease (HD) is a progressive, neurodegenerative movement disorder. Here, we used fast-scan cyclic voltammetry to measure dopamine release and uptake in striatal brain slices from R6/1 HD model mice. Peak dopamine release ([DA](max)) was significantly diminished in R6/1 mice
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