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15719

Sigma-Aldrich

D-Mannitol

meets analytical specification of Ph. Eur., USP, FCC, E421, 98.0-101.5% (calc. to the dried substance, HPLC)

Synonym(s):

Mannite

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About This Item

Empirical Formula (Hill Notation):
C6H14O6
CAS Number:
69-65-8
Molecular Weight:
182.17
Beilstein/REAXYS Number:
1721898
EC Number:
200-711-8
MDL number:
MFCD00064287
UNSPSC Code:
12352200
PubChem Substance ID:
22435040

assay

98-102% (calc. to dried substance)
98.0-101.5% (calc. to the dried substance, HPLC)

optical activity

[α]20/D +23 to +25°, c = 8% in Na2B4O7
[α]25/D +137 to +145

quality

meets analytical specification of Ph. Eur., USP, FCC, E421

impurities

acidity or alcalinity, complies
 reducing sugars, complies
 related substances, in accordance (HPLC)
 residual solvents, complies
 sorbit (DC), complies
≤0.007% free acid (as CH3COOH)
≤0.5% water (Karl Fischer)

ign. residue

≤0.1% (as SO4)

loss

≤0.3% loss on drying, 105 °C, 4 h

pH

5-7.5 (20 °C, 10%)

conductivity

20 μS/cm at 20 °C

mp

165-169 °C
167-170 °C (lit.)

anion traces

chloride (Cl-): ≤50 mg/kg
sulfate (SO42-): ≤100 mg/kg

cation traces

As: ≤1 mg/kg
Cu: ≤10 mg/kg
Ni: ≤1 mg/kg
Zn: ≤10 mg/kg

suitability

complies for appearance of solution
passes test for identity (IR)

SMILES string

OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO

InChI

1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4-,5-,6-/m1/s1

InChI key

FBPFZTCFMRRESA-KVTDHHQDSA-N

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Biochem/physiol Actions

A sugar alcohol sweet tastant. Used in sweetness inhibition studies.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

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Maria Badal Tejedor et al.
International journal of pharmaceutics, 486(1-2), 315-323 (2015-04-07)
Tablets are the most convenient form for drug administration. However, despite the ease of manufacturing problems such as powder adhesion occur during the production process. This study presents surface and structural characterization of tablets formulated with commonly used excipients (microcrystalline
Diana Bilton et al.
Thorax, 69(12), 1073-1079 (2014-09-24)
Bronchiectasis is characterised by excessive production of mucus and pulmonary exacerbations. Inhaled osmotic agents may enhance mucociliary clearance, but few long-term clinical trials have been conducted. To determine the impact of inhaled mannitol on exacerbation rates in patients with non-cystic
Heikki O Koskela et al.
Chest, 125(6), 1985-1992 (2004-06-11)
To define whether coughing during mannitol challenge is a nonspecific side effect of this challenge or is associated with asthma. A prospective study. University hospital. Thirty-seven steroid-naive, asthmatic subjects and 10 healthy subjects. The participants completed a symptom questionnaire, recorded
Heikki O Koskela et al.
Chest, 124(4), 1341-1349 (2003-10-14)
To compare the sensitivity and validity of mannitol, histamine, and cold air challenges to demonstrate the effect of inhaled corticosteroids (ICS) in asthma. A prospective study. Seventeen patients with recently diagnosed, steroid-naive asthma who fulfilled the diagnostic criteria of Finnish
Marieke Dubois et al.
Plant physiology, 169(1), 166-179 (2015-05-23)
Leaf growth is a tightly regulated and complex process, which responds in a dynamic manner to changing environmental conditions, but the mechanisms that reduce growth under adverse conditions are rather poorly understood. We previously identified a growth inhibitory pathway regulating
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