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147508

Sigma-Aldrich

Fertilysin™

97%

Synonym(s):

N,N′-Bis(dichloroacetyl)-1,8-octamethylenediamine, N,N′-Octamethylenebis(2,2-dichloroacetamide), N,N′-Octamethylenebis(dichloroacetamide)

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About This Item

Empirical Formula (Hill Notation):
C12H20Cl4N2O2
CAS Number:
1477-57-2
Molecular Weight:
366.11
EC Number:
216-033-0
MDL number:
MFCD00000841
UNSPSC Code:
12352103

assay

97%

SMILES string

ClC(Cl)C(=O)NCCCCCCCCNC(=O)C(Cl)Cl

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Carc. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
06010PG

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K Momma et al.
Fetal diagnosis and therapy, 9(1), 44-52 (1994-01-01)
Interrupted aortic arch type B associated with ventricular septal defect (n = 17) or atrioventricular septal defect (n = 2) was induced in 19 of 300 fetuses by maternal administration of bis-diamine on the 9th and 10th day of pregnancy.
John K Amory et al.
Journal of andrology, 32(1), 111-119 (2010-08-14)
The bisdichloroacetyldiamine WIN 18,446 reversibly inhibits spermatogenesis in many species, including humans; however, the mechanism by which WIN 18,446 functions is unknown. As retinoic acid is essential for spermatogenesis, we hypothesized that WIN 18,446 might inhibit retinoic acid biosynthesis from
H Tasaka et al.
Teratology, 43(3), 191-200 (1991-03-01)
Administration of N,N'-bis(dichloroacetyl)-1,8-octamethylenediamine, bisdiamine, in pregnant Donryu rats on day 10 of gestation induces a high incidence of cardiovascular anomalies in fetuses. Bisdiamine administration induced aplasia of the sixth aortic arch artery, with both the right and left primitive pulmonary
Takashi Hanato et al.
Birth defects research. Part B, Developmental and reproductive toxicology, 92(1), 10-16 (2011-02-12)
Conotruncal anomalies are often associated with abnormal coronary arteries. Although bis-diamine is known to induce conotruncal defects, its pathological effects on coronary vascular development have not been demonstrated. This study sought to assess the teratogenic effects of bis-diamine on coronary
Cathryn A Hogarth et al.
Biology of reproduction, 88(2), 40-40 (2013-01-04)
The BDADs (bis-[dichloroacetyl]-diamines) are compounds that can inhibit spermatogenesis via blocking the metabolism of vitamin A. We utilized one specific BDAD, WIN 18,446, to manipulate the endogenous production of retinoic acid (RA) in the testis to further investigate the action
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