128910

N,O-Bis(trimethylsilyl)acetamide

synthesis grade, ≥95%

• Synonym(s): BSA
• Linear Formula: CH₃C[=NSi(CH₃)₃]OSi(CH₃)₃
• CAS Number: 10416-59-8
• Molecular Weight: 203.43
• Beilstein/REAXYS Number: 1306669
• EC Number: 233-892-7
• MDL number: MFCD00008270
• UNSPSC Code: 12352103
• PubChem Substance ID: 24847878
• NACRES: NA.22

Properties

• grade: synthesis grade
• assay: ≥95%
• form: liquid
• refractive index: n20/D 1.417 (lit.)
• bp: 71-73 °C/35 mmHg (lit.)
• density: 0.832 g/mL at 20 °C (lit.)
• functional group: amine
• SMILES string: C\C(O[Si](C)(C)C)=N/[Si](C)(C)C
• InChI: 1S/C8H21NOSi2/c1-8(9-11(2,3)4)10-12(5,6)7/h1-7H3/b9-8+
• InChI key: SIOVKLKJSOKLIF-CMDGGOBGSA-N

Description

General description

N,O-Bis(trimethylsilyl)acetamide(BSA) is a powerful silylating agent for the protection of amides, amines, alcohols, carboxylic acids, enols and phenols. It can also be used as a Bronsted base precursor in Tsuji–Trost reactions. Additionally, it can be used to activate different functional groups during the production of nucleosides, peptides, and heterocycles.

Application

Derivatization reagent for GC-MS analysis of phenolic acids in fruits.

Reagent for the regioselective desulfation of polysaccharide sulfates. Also used to prepare trimethylsilyl ethers of carbohydrates and alcohols.

Features and Benefits

BSA is good moisture absorbent.

Safety Information

• pictograms: GHS02,GHS05,GHS07
• signalword: Danger
• hcodes: H226,H302,H314
• pcodes: P210 - P233 - P280 - P301 + P312 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Flam. Liq. 3 - Skin Corr. 1B
• supp_hazards: EUH014
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 3
• flash_point_f: 111.2 °F - closed cup
• flash_point_c: 44 °C - closed cup
• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges