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128775

Sigma-Aldrich

4-Hydroxypiperidine

98%

Synonym(s):

4-Piperidinol

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5 G
$37.50
25 G
$104.00
100 G
$141.40

About This Item

Empirical Formula (Hill Notation):
C5H11NO
CAS Number:
5382-16-1
Molecular Weight:
101.15
Beilstein/REAXYS Number:
102738
EC Number:
226-373-1
MDL number:
MFCD00005999
UNSPSC Code:
12352100
PubChem Substance ID:
24847875
NACRES:
NA.22

$37.50

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Quality Level

200

assay

98%

bp

108-114 °C/10 mmHg (lit.)

functional group

hydroxyl

SMILES string

OC1CCNCC1

InChI

1S/C5H11NO/c7-5-1-3-6-4-2-5/h5-7H,1-4H2

InChI key

HDOWRFHMPULYOA-UHFFFAOYSA-N

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General description

The molecular structure, vibrational spectra, NBO and UV-spectral analysis of 4-Hydroxypiperidine have been studied[1]. The compounds with a substituted 4-piperidinol core have been found to be potent antagonists of the human H(3) receptor[2].

Application

4-Hydroxypiperidine (4-Piperidinol) can be used in the synthesis of a highly potent and selective IP (PGI(2) receptor) agonist.[3] It can also be used in the study of copper-catalyzed N- versus O-arylation.[4]

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
SDBB1598
STBL2058
MKCB3394
STBG3027V
STBD0929V

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S Sebastian et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 75(3), 941-952 (2010-01-09)
In this work, we report a combined experimental and theoretical study on molecular structure, vibrational spectra, NBO and UV-spectral analysis of 4-Hydroxypiperidine (4-HP). The FT-IR solid phase (4000-400 cm(-1)), FT-IR gas phase (5000-400 cm(-1)) and FT-Raman spectra (3500-50 cm(-1)) of
Yasuhiro Morita et al.
Molecules (Basel, Switzerland), 17(2), 1233-1246 (2012-02-02)
An efficient synthesis of a highly potent and selective IP (PGI(2) receptor) agonist that is not structurally analogous to PGI(2) is described. This synthesis is accomplished through the following key steps: Nucleophilic ring-opening of 3-(4-chlorophenyl)-oxazolidin-2-one prepared by a one-pot procedure
N- versus O-arylation of aminoalcohols: orthogonal selectivity in copper-based catalysts.
Alexandr Shafir et al.
Journal of the American Chemical Society, 129(12), 3490-3491 (2007-03-08)
James T Anderson et al.
Bioorganic & medicinal chemistry letters, 20(21), 6246-6249 (2010-09-14)
Compounds containing a substituted 4-piperidinol core have been found to be potent antagonists of the human H(3) receptor. The compounds exhibited up to a 60-fold preference for inhibiting the human H(3) receptor over the mouse and showed a low binding

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    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
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      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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