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COO/COA

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100633

1-(2-Hydroxyphenyl)-3-phenyl-2-propenone

Name: 1-(2-Hydroxyphenyl)-3-phenyl-2-propenone
Brand: ALDRICH

98%

Synonym(s):

2′-Hydroxychalcone, 2-Hydroxybenzalacetophenone

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About This Item

Linear Formula:

C₆H₅CH=CHCOC₆H₄OH

CAS Number:

1214-47-7

Molecular Weight:

224.25

Beilstein/REAXYS Number:

976324

EC Number:

214-928-0

MDL number:

MFCD00016441

UNSPSC Code:

12352100

PubChem Substance ID:

24846420

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assay

98%

mp

86-88 °C (lit.)

SMILES string

Oc1ccccc1C(=O)\C=C\c2ccccc2

InChI

1S/C15H12O2/c16-14-9-5-4-8-13(14)15(17)11-10-12-6-2-1-3-7-12/h1-11,16H/b11-10+

InChI key

AETKQQBRKSELEL-ZHACJKMWSA-N

Gene Information

human ... IL1B(3553)
rat ... Alox5(25290)

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Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Lot/Batch Number

04808KI

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Chemoprevention of 4-nitroquinoline 1-oxide-induced rat oral carcinogenesis by the dietary flavonoids chalcone, 2-hydroxychalcone, and quercetin.

H Makita et al.

Cancer research, 56(21), 4904-4909 (1996-11-01)

The modifying effects of dietary exposure of three flavonoids, chalcone, 2-hydroxychalcone, and quercetin, during the initiation and postinitiation phases of oral tumorigenesis initiated with 4-nitroquinoline-1-oxide (4-NQO) were investigated in male F344 rats. At 6 weeks of age, animals were divided

[Synthesis of structural fragments of natural flavonoids and flavolignans from 2'-hydroxychalcones].

G O Ismailova et al.

Bioorganicheskaia khimiia, 38(3), 382-384 (2012-09-25)

Structural analogues of natural flavonoids and flavolignans - new 2'-OAc-chalcones and 2-hetaryl-3-aminochromons with the remnants of a 6-halogen-1,3-benzodioxane, 1,4-benzodioxane and 1,5-benzodioxepan were synthesized. Structure of the obtained compounds was confirmed by the 1H NMR data.

High-performance liquid chromatography separation of enantiomers of flavanone and 2'-hydroxychalcone under reversed-phase conditions.

Roberto Cirilli et al.

Journal of chromatography. A, 1190(1-2), 95-101 (2008-03-21)

A reversed-phase high-performance liquid chromatography (HPLC) method was developed for evaluating the chiral discrimination ability of Chiralpak IA chiral stationary phase (CSP) towards flavanone. The effect of the nature and pH buffer as well as nature of alcohol modifier on

Growth inhibition of oral bacteria related to denture stomatitis by anti-candidal chalcones.

M Sato et al.

Australian dental journal, 42(5), 343-346 (1997-12-31)

In the antimicrobial therapy of denture stomatitis, it is desirable to inhibit the growth of not only the primary causative organism, Candida albicans, but also other oral bacteria closely associated with the condition. Three synthetic anti-candidal chalcones were characterized and

Microwave-assisted reaction of 2'-hydroxychalcones with hydrazides to synthesize flavanone hydrazone and 4,5-dihydropyrazole derivatives.

Aihua Nie et al.

Journal of combinatorial chemistry, 8(5), 655-658 (2006-09-12)

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