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P115

Supelco

Prazosin hydrochloride

Synonym(s):

Prazosin HCl, 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride, Furazosin hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C19H21N5O4 · HCl
CAS Number:
19237-84-4
Molecular Weight:
419.86
Beilstein/REAXYS Number:
4303561
EC Number:
242-903-4
MDL number:
MFCD00058177
UNSPSC Code:
41116107

form

solid

color

white

mp

277-280 °C

SMILES string

Cl.COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)c4ccco4

InChI

1S/C19H21N5O4.ClH/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22);1H

InChI key

WFXFYZULCQKPIP-UHFFFAOYSA-N

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General description

hygroscopic, light sensitive

Biochem/physiol Actions

α1- and α2Β−adrenoceptor antagonist; MT3 melatonin receptor antagonist.

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Description
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pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Repr. 2 - STOT RE 2 - STOT SE 3

target_organs

Central nervous system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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S Morishima et al.
British journal of pharmacology, 153(7), 1485-1494 (2008-01-29)
In addition to alpha1A, alpha1B and alpha1D-adrenoceptors (ARs), putative alpha1L-ARs with a low affinity for prazosin have been proposed. The purpose of the present study was to identify the alpha1A-AR and clarify its pharmacological profile using a radioligand binding assay.
Ryouhei Tsutsumi et al.
Molecular and cellular biology, 29(2), 435-447 (2008-11-13)
The heterotrimeric G protein alpha subunit (Galpha) is targeted to the cytoplasmic face of the plasma membrane through reversible lipid palmitoylation and relays signals from G-protein-coupled receptors (GPCRs) to its effectors. By screening 23 DHHC motif (Asp-His-His-Cys) palmitoyl acyl-transferases, we

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